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Extractable Nuclear Antibodies (ENA) Blood Test

 


EXTRACTABLE NUCLEAR ANTIBODIES (ENA) BLOOD TEST

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£120.00
£120.00 - £120.00
£120.00
£0.00 - £120.00
£0.00
1 biomarker
9 days
Instructions
FAQ

The Extractable Nuclear Antibodies (ENA) blood test detects the presence of autoantibodies in your blood. These autoantibodies mistakenly target and attack the body's own tissues.

Simple and accurate blood test from a laboratory you can speak to.

Please note that this test panel requires special consideration and will not appear on your health dashboard. You will be emailed your results as soon as they're available.



STEP 1 - CHOOSE YOUR SAMPLE COLLECTION OPTION
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EXTRACTABLE NUCLEAR ANTIBODIES (ENA) BLOOD TEST OVERVIEW

Our ENA (Extractable Nuclear Antigen/Antibodies) blood test is a panel of specific antibody tests used to help diagnose and evaluate certain autoimmune conditions, primarily connective tissue diseases.

By detecting the presence of autoantibodies that target proteins within a cell’s nucleus, this test provides valuable insights into conditions such as systemic lupus erythematosus (SLE), Sjögren’s syndrome, scleroderma, and mixed connective tissue disease.

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EXTRACTABLE NUCLEAR ANTIBODIES (ENA) BLOOD TEST

The ENA blood test, or Extractable Nuclear Antigen panel, is a crucial diagnostic tool used to detect specific autoantibodies associated with connective tissue diseases such as Systemic Lupus Erythematosus, Sjögren’s syndrome, scleroderma, and mixed connective tissue disease.

By identifying these unique markers in the bloodstream, you can accurately pinpoint the cause of persistent symptoms like joint pain, fatigue, and dry eyes or mouth. 

This panel includes the following:

  • Anti-Smith (Anti-Sm): Often associated with systemic lupus erythematosus (SLE) and considered quite specific for that condition.

  • Anti-RNP (Ribonucleoprotein): Frequently linked to mixed connective tissue disease (MCTD) but can also appear in lupus and other conditions.

  • Anti-SSA (Anti-Ro) and Anti-SSB (Anti-La): Commonly seen in Sjögren’s syndrome; may also appear in lupus.

  • Anti-Scl-70 (Anti-topoisomerase I): Associated with scleroderma (systemic sclerosis).

  • Anti-Jo-1: Often indicates polymyositis or dermatomyositis, particularly when lung involvement is present.

6 BIOMARKERS

  1. ANTIBODIES

    - Extractable Nuclear Antibodies: (nRNP, Sm, Ro ,La, Jo1, Scl70)

  2. TURNAROUND TIME

    - 9 days

  1. TURNAROUND TIME

    We are extremely fast, with some results available within hours and others within a working day or less, from the time your sample is in our lab. However, this is not a guarantee and should not be taken as such. This is the guideline turnaround time that can be shorter or longer.


    THIS IS NOT A GUARANTEED TURNAROUND TIME.


    We are extremely proud of our very short turnaround times and a very efficient laboratory processes, you will start receiving results as soon as they are available and have completed clinical validation.


    Whilst we accommodate the shortest of time scales, with some results available within hours, for this particular test the usual turnaround time is: 9 working days.

  1. CAN I SEE A GP TO DISCUSS MY RESULTS?

    Yes, usually the same or next day.


    One Day Tests has a fantastic clinical team of consultants and GPs. Once you have your results you can book an online video consultation to discuss your results.


    Our clinical team consists of practicing NHS and private GPs, who work closely with our laboratory and can tell you what your blood test results mean for you. Having an integrated laboratory and GP services makes your health journey seamless and extremely efficient.


    This service is not included in the price of the test, it is charged separately, should you wish to book it.

DOCTOR'S COMMENTS

Hi, I am Dr. Adam Staten and here's my view on this test as a GP and Clinical Director at One Day Tests.

DR. ADAM STATEN - GP VIEW AND RED FLAG SYMPTOMS

Common signs and symptoms that may warrant an ENA (Extractable Nuclear Antigen) blood test include persistent joint pain or swelling, unexplained fatigue, skin rashes, dry eyes or mouth (common in Sjögren’s syndrome), and muscle weakness.

These manifestations can indicate an underlying autoimmune or connective tissue disorder, such as lupus, scleroderma, Sjögren’s syndrome, or mixed connective tissue disease, and an ENA test can help pinpoint the specific antibodies involved.

Red flag symptoms for the Extractable Nuclear Antibodies (ENA) Blood Test

Please contact your GP if you are experiencing persistent symptoms of any kind, including muscle weakness and severe fatigue.

Your Results

The results of your Extractable Nuclear Antibodies (ENA) Blood Test will be emailed to you as a secured PDF file, ready for your GP.

SAVE ON CONTINUOUS MONITORING WITH OUR SUBSCRIPTION PLAN

The best way to look after your health is to do so regularly. This is easy to do with our continual monitoring plans which give you a discount on future blood tests. You choose the frequency and we'll do the rest.

When you purchase a subscription, we will deliver your home test kits or allow you to book appointments in line with your chosen frequency. There is a minimum of 3 tests with any subscription, after which you can pause/restart/cancel at any time.

SPECIAL INSTRUCTIONS

Hi, I am Stefania Brown, I am the Laboratory Manager at One Day Tests and here are the lab's special requests for the Extractable Nuclear Antibodies (ENA) Blood Test.

SPECIAL INSTRUCTIONS

There are no special instructions for this test.

Clinic appointment - how to prepare for the Extractable Nuclear Antibodies (ENA) Blood Test

If you are coming into one of our clinics for the test, this is what you need to do before you arrive:

  • Read the instructions in the SPECIAL INSTRUCTIONS section
  • Drink plenty of water about an hour before the appointment.
  • Avoid coffee/tea/energy drinks. Water is good!
  • That’s it! We’ll do the rest.

Home test kit - how it works with the Extractable Nuclear Antibodies (ENA) Blood Test

Our blood test kits are simple and convenient.

The most important step in doing a blood test at home is to read the instructions very carefully. The process is very simple, but there are a few pitfalls you need to be aware of - you will save yourself a lot of time if you do it right the first time around!

  • Full printed instructions will arrive with your kit - please read them carefully.
  • Drink plenty before taking the sample and warm your hands up in the sink with warm water for a few minutes. This will make your blood flow much better.
  • Fill the tubes to the top line. We don’t need much blood; filling tubes to the top line is about 15 drops of blood.
  • Post the samples on the same day you take them, before midday, Monday to Thursday. If you post it any other time it might get to us late or be stuck at a sorting office over the weekend. You will then have to do it again.
  • Package the sample in the same box the kit came in. Otherwise, Royal Mail or DPD will reject it. The sample tubes go into a pouch, then into a cardboard box, and then into a return envelope. All of this is provided in the kit: please use it.

We look forward to receiving your sample in our lab!

HOW OUR HOME KITS WORK

How the finger prick home blood test kit for Extractable Nuclear Antibodies (ENA) Blood Test works - from Dr. Adam Staten

Follow our step by step instructions on how to take your sample quickly and easily using the blood sample collection finger prick test.

WHY CHOOSE US?

Hello! My name is Dr. Vinesh Mistry, I am part of the GP team here at One Day Tests and here is why you should trust us to test your blood.

QUICK AND ACCURATE RESULTS DIRECT FROM A LABORATORY.

We run our own regulated laboratories and our own accredited clinics. We manufacture our own approved home sample collection kits. Your results are looked after by our fantastic clinical governance team and our super-talented biomedical science team.

When you book your test with us - you book directly with the lab. This means accuracy and responsible duty of care, direct access to the provider and extremely fast turnaround times.

Finally, our customer services rock! You can ask the lab a question any time or you can speak to a real human. You can email us on hello@onedaytests.com or give us a call on 0127 309 2844.

FREQUENTLY ASKED QUESTIONS

Hi, I am Lana Nela, Lead Nurse, and here is what we are frequently asked about this test.

FREQUENTLY ASKED QUESTIONS

Here are some of the most frequently asked questions about the Extractable Nuclear Antibodies (ENA) Blood Test.

Can an ENA test be negative and still indicate autoimmune disease?

Yes. While the ENA panel is highly useful, not every person with an autoimmune disorder will have positive ENA results.

Additional or alternative tests (e.g., ANA, rheumatoid factor) may be necessary for a complete assessment, depending on symptoms.

WHY HAVE THE TEST?

Hi, I am Nader Eldarf, I am a Biomedical Scientist in our laboratory and here is why it's important to take this test.

  1. WHY HAVE THE EXTRACTABLE NUCLEAR ANTIBODIES (ENA) BLOOD TEST?

    The ENA blood test helps narrow down which specific autoimmune condition you may have.

    Each autoantibody in the panel corresponds to different connective tissue diseases or disease markers.

IS THIS TEST RIGHT FOR YOU?

Hi, I am Sandeep Patel, I am the Laboratory Director at One Day Tests. Here are the symptoms that you may wish to address with this test.

  1. IS THE EXTRACTABLE NUCLEAR ANTIBODIES (ENA) BLOOD TEST RIGHT FOR YOU?

    You should have the ENA panel blood test if you are experiencing symptoms suggestive of an autoimmune disorder.

    These may include chronic joint pain, persistent fatigue, rashes, dry eyes or mouth, and lack of energy complaints.

    If you have tested positive for antinuclear antibody (ANA) test or experiencing unexplained inflammation, this may warrant an ENA panel to pinpoint the issue more specifically.

  1. SYMPTOMS AND TAGS

WHY ARE BLOOD TESTS IMPORTANT?

Health monitoring is very important, you are in charge of your health - look after it.