ESR BLOOD TEST

ESR (Erythrocyte Sedimentation Rate) is a blood test that is used to test for inflammation. The ESR may be raised in many different conditions ranging from infection and injuries to autoimmune and other inflammatory conditions.

It is also used more specifically in the diagnosis of Temporal Arteritis and Polymyalgia Rheumatica.

A high level of ESR does not give a diagnosis by itself but suggests that something is causing inflammation within the body. The cause of this may be obvious, such as infection, but sometimes other investigations and examinations may be necessary to determine the cause. ESR also tends to rise with age and may be elevated in pregnancy.

A low ESR is not usually clinically significant but may be seen in some rarer blood disorders. 

This test must be taken after 12:00 (midday), unless you are coming to any of our London clinics. At all other clinics it must be taken after 12:00 (midday), so please book your appointment accordingly.

IT WILL BE REJECTED BY THE LABORATORY IF THIS IS NOT FOLLOWED.

What is an ESR (Erythrocyte Sedimentation Rate) test?

An ESR test measures how quickly your red blood cells (erythrocytes) settle to the bottom of a test tube over a specific period (usually one hour). In a healthy state, red blood cells sink relatively slowly. However, when your body is fighting inflammation or infection, it produces proteins, like fibrinogen, that cause blood cells to cluster and settle faster.

The ESR test thus provides a general marker of inflammation in the body. Although it doesn’t pinpoint a specific condition by itself, it often serves as a clue that further investigation is needed.

What conditions can an ESR test help diagnose or monitor?

The ESR test is used to detect and track a wide range of conditions related to inflammation or abnormal immune responses, such as:

Autoimmune disorders (e.g., rheumatoid arthritis, systemic lupus erythematosus): ESR can rise when immune responses attack the body’s own cells.

Infections (bacterial or certain chronic infections): Elevated ESR can hint at persistent inflammation caused by an infection.

Chronic inflammatory diseases (e.g., inflammatory bowel disease): ESR levels often correlate with the severity of the inflammatory process.

Certain cancers: While ESR is not a cancer test, a persistently high ESR may prompt doctors to rule out underlying malignancies if other risk factors are present.

It’s important to remember that a higher (or lower) ESR does not provide a definitive diagnosis. Your GP would typically use ESR in conjunction with other blood tests, imaging, and clinical evaluations to pinpoint the exact cause of inflammation.

Why is the ESR test important for my overall health assessment?

Early Indicator of Inflammation: Because ESR goes up in response to inflammation, it can alert doctors to hidden or ongoing inflammatory processes before more obvious symptoms appear.

Monitoring Disease Progression: In chronic conditions such as rheumatoid arthritis, periodic ESR measurements help track how well treatments are working or whether the disease is flaring.

Guiding Further Testing: An elevated or abnormal ESR doesn’t diagnose a disease on its own, but it does prompt additional tests (like CRP, imaging, or specific antibody tests) to uncover the root cause.

Assessing Treatment Effectiveness: Decreases in ESR over time can indicate that a chosen therapy is reducing inflammation, which can help doctors fine-tune medications or treatment plans.

In essence, the ESR test is a useful screening and monitoring tool for understanding inflammatory activity in your body. While it’s not diagnostic by itself, it can be an important piece of the puzzle in keeping your health on track.